Louis Breslow (née Lewis Breslow; July 18, 1900 – November 10, 1987) was an American screenwriter and film director. He wrote for 70 films between 1928 and 1955. He also directed seven films between 1932 and 1951 and wrote scripts for both Laurel and Hardy in their first two films at 20th Century Fox, and Abbott and Costello.

Lou Breslow married film actress and comedienne Marion Byron in 1932, and remained married until her death in 1985.