Very little was released publicly regarding the plot of the remake and the extent to which it would be faithful to the original. It was expected that the central focus would be on three teenagers in a family of vampires traveling Route 66 in the late 1980s.
The plot line focuses on the Lassader family, headed by Joe and Carol, whose daughter Selena searches out Derek McGregor and his team to hunt and kill a vampire colony that is holding the family hostage by drinking the blood of their livestock, the source of their income. Accepting the offer, McGregor and his small team begin a bloody, terrifying journey to track and destroy the evil vampire brood, with the help of vampire specialist Xavier Burns.
Count Murnau, a wealthy eccentric from the Carpathian region wishes to buy a property in Hannover, Germany. The real estate agency sends Mr. Dohart, his best sales representative to close the deal, but Dohart never gets back. The real state agency sends the young and newlywed Hutter to take care of this matter, and he departs alone to Transylvania leaving his wife Ellen waiting for his return.
Klaha and Cecil are set to get married. However, their wedding must be postponed because Klaha is summoned from England to Romania on business. Klaha goes to Transylvania, and arrives at the Earl of Dracula's castle, where he is staying. The Earl seems welcoming, but Klaha has strange experiences while staying there. On his arrival, he notices a painting of the Earl's deceased wife, who looks very much like Cecil. 2 nights later, the Earl agrees to buy a house in England. That same night, after having a nightmare, Klaha wakes up to see a coffin leaving the grounds. While looking for the Earl, Klaha sees the painting again, but this time, the word "Cecil" is written under it. Too late does Klaha realise that the Earl is a vampire. He immediately leaves to try to catch up with him.
A feminist blogger and reporter for the school newspaper, tries to stop Countess Elizabeth Báthory, who poses as an abstinence counselor in a high school, from killing the school's virgins to stay young and beautiful.
Gretchen (Sean Serino), a young woman, becomes desperate to contact her brother after his passing. She discovers an amulet that allows her to control the dead—which she uses to try and contact him. The amulet also allows results in the calling forth of a small army of zombies, comedically called "Post-Mortem Americans" in the film. This amulet is a sought after relic, pursued by two feuding vampires who have been at odds for millennia: Vellich (Andrew Divoff) and Sebed (Tom Savini). After encountering the vampires, Gretchen and her friends are joined by the vampire-hunter McCallister (Jason Carter), who had originally stolen the amulet from Vellich. McCallister helps Gretchen and her friends combat the villains, and the film ends with a final showdown between the protagonists and the vampires. The film was called a "vampire-zombie hybrid movie" by the Columbus Dispatch.
La ville de Barrow en Alaska connaît un mois sans soleil tous les ans en hiver. Alors que les habitants se préparent, un étranger (Ben Foster) débarque d'un grand navire et sabote les communications et les moyens de transport de la ville vers le monde extérieur. Le shérif de Barrow, Eben Oleson (Josh Hartnett), enquête sur ces actes criminels tout en apprenant que son ex-femme, Stella (Melissa George), a manqué le dernier avion et doit rester tout le mois. Cette nuit-là, une bande de créatures humanoïdes semblables à des vampires, et dotée d'une force et d'une vitesse surhumaines, attaque et massacre la plupart des habitants, forçant Eben, Stella, le petit frère d'Eben, Jake (Mark Rendall), et d'autres survivants à se cacher dans le grenier d'une maison. Les vampires trouvent l'étranger menotté aux barreaux du poste de police local. Celui-ci croit qu'ils vont le transformer en ce qu'ils sont pour le remercier de ce qu'il a fait. Cependant, ils n'en font rien et le tuent.
Une année après avoir survécu aux massacres de Barrow en Alaska, Stella Olemaun (Kiele Sanchez) déménage à Los Angeles, où elle fait exprès d’attirer l’attention de la population locale de vampires et veut à tout prix faire éclater la vérité sur ce qui s'était vraiment passé en Alaska. Personne ne la croit ; les adultes se moquent d'elle et la jeune femme devient le souffre-douleur de l'intégralité des enfants de la ville. Elle reste déterminée à venger la mort de son mari, Eben.
In a posh London gallery, Carolyn Dalgleish (Carolyn Backhouse) prepares a showing of the latest works by John Bolton; disturbing portraits of beautiful, vicious vampiric women he encountered whilst pot holing. The Interviewer (Marcus Brigstocke) collects information on Bolton, who seems to perplex those who work with him and collect his art (like radio personality Jonathan Ross (playing himself)).
A Miami businessman, John Stone, receives a parcel from England containing two old bottles of Slivovitz brandy from his recently deceased ancestor, and after drinking both bottles, becomes a vampire. Stone uses his newfound vampire powers to keep his wife, Helena, in a trance as he travels to England to kill the descendents of Abraham Van Helsing that murdered Count Dracula. Meanwhile, Helsing's distant relative, Howard Helsing, pursues Stone with the intent to put the reborn vampire to rest for good.
Abraham Lincoln, le seizième président des États-Unis, mène une guerre contre les vampires, tandis que ceux-ci s’apprêtent à prendre possession du pays. Sa mission est de les exterminer.