This is not a Bulldog Drummond picture despite the title playing off Jack Buchanan and his previous association with the character. Here he plays the role of Test Pilot 'Bulldog' Bill Watson. His friend Derek Sinclair (Sebastian Shaw) is convinced that the new man in his love's life is collaborating with the Nazis by sabotaging an armaments plant.
The film loosely follows the central plot of Fleming's novel. British secret agent James Brum infiltrates the Pub Royale where he beats opponent Le Dough at a high-stakes monopoly game. Escaping from Le Dough's beautiful mistress Lenya, Brum gives chase to Le Dough on a modified bicycle to rescue love-interest Lambretta. In the climax Brum sellotapes live hedgehogs to the road which puncture the tyres of Le Dough's sports car and it hurtles over a cliff.
Vijay (Chiranjeevi) is a CBI agent who lives in Delhi. On a special operation, Vijay is sent a place where a gang is involved in a crime. His job is to gain evidence against them and bring them to justice. Vijay succeeds in bursting the gang and in the due process, he meets Rekha (Radhika Sarathkumar) and falls for her. Vijay manages to liquidate the boss of that gang and returns to Delhi with Rekha as his wife.
A French spy, Captain Paul Benoit, manages to steal some German secrets. The Germans send Erna Fielder, an agent of their own, after him, but the two spies end up falling in love.
Ten years before the first film, there was a period of enormous political turmoil. Fearless agents were recruited for espionage missions against enemy spies. Gregorio Cortez and Ingrid Avellan (Antonio Banderas and Carla Gugino) were enemy spies assigned to kill each other, but instead they fell in love and married. After an atypical wedding, Gregorio and Ingrid took a break from espionage and started a family.