Apocalypse III: Tribulation is a 2000 thriller film by Cloud Ten Pictures, starring Gary Busey, Howie Mandel, Nick Mancuso, and Margot Kidder. The film is the second sequel to Apocalypse, although its first half is set prior to the events of the previous film.
The film tells the story of Tom Camboro (Gary Busey), a police detective who finds himself battling a mysterious group with psychic powers. When his wife (Sherri Miller), sister (Margot Kidder), and brother-in-law (Howie Mandel) become the target of this dark society, he rushes to their aid, but is incapicated before he can intervene. Tom awakens from a coma two years later to discover a transformed world. All Christians have vanished in the Rapture, and most of the world worships the Antichrist (Nick Mancuso).
A subplot continues the tale of Helen Hannah (Leigh Lewis), one of the leading members of the Resistance to the Antichrist.
It is the present day. In their home, the family Camboro - Eileen, Calvin and Tom – reminisce a childhood memory of an afternoon picnic. Tom’s brother-in law Jason abruptly enters the kitchen. Jason makes unsettling comments about European President Franco Macalousso, an outspoken advocate for global peace and unity. Tom Camboro believes that Jason needs psychiatric help, to the disagreement of his wife Suzy, who distrusts hospitals and doctors.